Objective To investigate the correlation between renal insufficiency and prognosis ofacute ischaemic stroke patients with non-valvular atrial fibrillation. Methods Totals of 266 acute isch-aemic stroke patients with non-valvular atrial fibrillation in Neurology Department，Xuan Wu Hospital between January 2013 and January 2015 were included. Estimated glomerular filtration rate (eGFR) was estimated byrevised Modification of Diet in Renal Disease (MDRD) equation. Renal inadequacy is defined as eGFR＜60 ml/(min·1.73 m2).There were 36 cases in renal inadequacy group and 230 cases in renal adequacy group. The followed-up du-ration lasted for 1 year. The association between eGFR and poor stroke outcomes was evaluated by multivariate analysis. Results (1) The proportion of patients older than 65 years in renal inadequacy group was bigger than renal adequacy group ［94.4%(34/36) vs 70.0%(161/230)，P=0.002］. (2)There was statistical difference be-tween renal inadequacy group and renal adequacy group on rate of outcome events (50.5% vs 29.6%，P=0.021).(3)Multivariate logistic regression analysis showed that eGFR ＜60 ml/(min·1.73 m2) was an independent riskfactor for the occurrence of endpoint events within 1 year after acute cerebral infarction. The worse renal function was，the higher incidence of poor stroke outcomes would be(OR=1.485，P ＜0.05). Conclusions The renal function would become worse with the growth of age in acute ischemic stroke patients with non-valvular atrialfibrillation. Renal insufficiency is an independent risk factor for the occurrence of endpoint events in acute cere-bral infarction patients with non-valvular atrial fibrillation.