Objective To investigate the distribution of serum folate，vitamin B12 and ferritin in patients with schizophrenia. Methods Blood samples were collected from 1 042 patients with schizophrenia. Levels of serum folate，vitamin B12 and ferritin were detected by electrochemiluminescence immunoassay. Re-sults The prevalence of low vitamin B12，folate and ferritin levels in schizophrenia patients was generally higherthan 5%. And the prevalence of low folate was as high as 38.29%. The prevalence of low vitamin B12 was about 18.14%. There were gender differences in levels of folate (t=-5.83，P ＜0.01)，and age differences in levels of vitamin B12 (t=2.08，P ＜0.05) in patients with schizophrenia. Conclusions The prevalence of low serum vita-min B12，folate and ferritin levels in patients with chronic schizophrenia is high，which need to be actively con-cerned about.