bjective To explore the application and clinical significance of one stop whole brain dynamic volume CTP-CTA imaging in cerebral vasospasm after traumatic brain injury. Methods Totals of 50 patients with suspected symptomatic cerebral vasospasm were treated with one stop whole brain dynam-ic volume imaging. The results of CTP were compared with that of the contralateral mirror area. Results In 50 patients，48 showed low perfusion areas outside the scope of brain injury which was consistent with clinical symptoms. The accuracy rate was 96%. There were significant differences in cerebral blood flow (CBF)，cerebral blood volume (CBV)，time-to-peak (TTP) and mean transit time (MTT) compared to the contralateral mirror area. In 50 traumatic brain injury patients，42 showed intracranial vasospasm of great vessels in 3D-CTA. Conclusions One-stop whole brain dynamic volume CTP-CTA imaging could be applied in evaluating cerebral vasospasm after traumatic brain injury. Microcirculation vasospasm in brain parenchyma could be detected by low perfusion cerebral area in CTP. Vasospasm of great vessels outside brain parenchyma could be detected by CTA. Therefore，CTP combined with CTA has significant clinical value in early diagnosis，selection of treatment options and evaluation of efficacy for cerebral vasospasm after traumatic brain injury.