Objective To explore the characteristic of clinical interventions and treatment efficacy of acute schizophrenic inpatients with aggressive behaviors before admission. Methods Totals of 151 acute schizophrenic inpatients were recruited and divided into two groups (group A: patients with aggressive behaviors; group B: patients without aggressive behaviors) based on score of the Modified Overt Aggression Scale (MOAS). Disease information and clinical interventions were recorded using the self-made questionnaire. The aggressive behaviors occurred one week before the hospitalization，the agitation symptoms，the nurse risks，the severityand treatment efficacy of the subjects were evaluated using the Modified Overt Aggression Scale (MOAS)，thePositive and Negative Syndrome Scale Excited Component (PANSS-EC)，the scale of assessment on nurse risks and the Clinical Global Impression (CGI). Results (1) Of 151 inpatients，74 cases had aggressive behaviorsbefore admission，and 77 cases didn’t. (2) Compared to inpatients in group B，the rate of inpatients in group A on previous violent/aggressive behavior and the proportion on no drug administration were all higher (P ＜0.05).The severity of disease was higher in group A (P ＜0.05). The scores of CGI-SI，PANSS-EC、BARS and MOAS，and the risk of aggression and rate of anti-attack care advice were also higher in group A (P ＜0.05). (3) All in-patients were prescribed by the second generation antipsychotics. The ratio of risperidone was 68.9%，followed by olanzapine (13.2%) and quetiapine (5.3%). The ratios of haloperidol intramuscular injection and safeguard re-straint usage in group A were more than those in group B (P ＜0.05). (4) There were no significant differences on the scores of CGT-SI，MOAS，PANSS-EC， diseases severity and the days of stay in hospital between two groups (P＞0.05). Conclusions The treatment efficacy of the inpatients with aggressive behaviors before admission is as same as that of inpatients without aggressive behaviors. The inpatients with aggressive behaviors have moreagitation symptoms and higher risk of aggression and flee. During hospitalization，the applications of haloperidol intramuscular injection and safeguard restraint in patients with aggressive behaviors were more frequently.