Objective To explore the correlation between the blood-brain barrier dysfunction and clinical prognosis in patients with Guillain-Barre syndrome (GBS). Methods Totals of 78 patients with GBS in department of neurology were followed-up from January 2013 to June 2016. All patients were divided into two groups based on Hughes scale at 6 months：the good prognosis group (Hughes ＜3) and poor prognosis group (Hughes ≥3). Clinical and biochemical data，as well as immunotherapy were analyzed. Results Between the good and poor prognosis groups，there were no significant differences in gender，age，onset season，proceedinginfection，pneumonia，mechanical ventilation，cerebrospinal fluid protein，immunoglobulin G，IgG-index，intrathecal IgG synthesis rate within 24 hours，injury of nerve axonal and immunotherapy (P ＞0.05). There were statistically significant differences in score of muscle strength on admission and albumin CSF/serum ratio(QALB) (χ2=11.73，8.01；P ＜0.05). Blood-brain barrier dysfunction was positively correlated with clinical poor prog-nosis (r=0.32，P ＜0.01). Conclusions The blood-brain barrier dysfunction in patients with GBS is associated with poor prognosis. Therefore，blood-brain barrier permeability may be used to predict the prognosis of patient with GBS.