Objective To compare the differences of neuropsychological profile between patients with dementia with lewy bodies （DLB）and Parkinson disease dementia （PDD）. Methods A total of 20 DLB patients and 56 PDD patients were recruited in this study. Mini-mental State Examination（MMSE），Clock-draw-ing Test （CDT），Neuropsychiatric Inventory （NPI），Activities of Daily Living Scale （ADL），Hamilton Depression Scale（HAMD）and Clinical Dementia Rate （CDR）were used to evaluate the cognitive function. Results A total of 60% of DLB patients had fluctuant symptoms，significantly higher than PDD patients （19.6%，P=0.001）. In the moderate and severe stage of dementia，the NPI scores of DLB group were significantly higher than that of PDD group （P＜ 0.05）. In the mild dementia stage，the scores of the family life and personal hobby domain in CDR were higher in PDD patients than that in DLB patients （P=0.039）. In the moderate and severe stage，the memory score （P=0.018），orientation score （P=0.010）and overall CDR score （P=0.028）in DLB group were higher than that in PDD group. Conclusions Comprehensive neuropsychological tests combined with clinical historycan help identify DLB and PDD in dementia patients.