Objective To investigate the status of medicine compliance in secondary prevention of ischemic stroke,in order to provide evidence for the secondary prevention. Methods Data of 242 con-tinuous ischemic stroke patients in Urumqi were prospectively collected. Information of medicine and reasonsof ceasing durgs was registered in 12 months. Results The rate of taking antithrombotic drugs one year after discharged was 55.8%(135/242). The nationality (OR=4.007,95%CI=1.768-9.080),degree of education (OR= 2.953,95%CI=1.493-5.840),pattern of payment (OR=0.189,95%CI=0.060-0.594),dyslipidemia(OR=0.424, 95%CI=0.217-0.831)were associated with treatment compliance one year after discharged. The rate of takingstains one year after discharged was 59.9%(145/242). The degree of education(OR=3.613,95%CI=1.844- 7.082), pattern of payment (OR=0.254,95%CI=0.091-0.711),dyslipidemia(OR=0.340,95%CI=0.179-0.648) were associated with compliance of medicine one year after discharged. The rates of taking hypotensor and hy-poglycemic agent one year after discharged were 71.9%(138/192)and 64.8%(59/91). The main reasons of poor compliance of antithrombotic drugs and stains were symptoms improved and ignoring the treatment. The mainreasons of poor compliance of hypotensor and hypoglycemic agent were indicators improved and ignoring thetreatment. Conclusions The treatment compliance in secondary prevention of ischemic stroke patients is gen-erally poor. The clinicians should focus on the secondary prevention guidance.