Objective To discuss the risk factors of cerebral microbleeds（CMBs）in ischemic stroke patients for secondary prevention in order to provide guidance for the prevention and treatment ofcerebrovascular disease. Methods Patients with acute ischemic stroke were enrolled in the study. They re-ceived susceptibility weighted imaging （SWI）within 4d after initiation of antiplatelet treatment. After 12-month follow-up，the patients received SWI again. The presence and number of CMBs at baseline and during follow-up were documented. Results Totals of 94 patients with acute ischemic stroke were enrolled and 50 patients （53.2%）companied CMBs. Bivariate Logistic regression analysis showed that hypertension （OR=1.2，95%CI=1.07-1.61， P=0.004）and age （OR=2.2，95%CI=1.25-3.92，P=0.006）were independent risk factors of CMBs. With increas-ing of age for 10 years，the incidence of CMBs would increase 2.2 times. ROC curve showed that the area under the age curve was 0.695（95%CI=0.588-0.802）and the best cutoff of predictive age was 62 years old. The riskof CMBs increased significantly in patients who was older than 62. There were 22 cases received SWI again after fol-low-up，and 33 new CMBs lesions were identified. Wilcoxon nonparametric matched-pairs test revealed significantdifference between numbers of CMBs before and after follow-up（1 vs 2.5，Z=-3.1，P=0.002）. Conclusions Patients older than 62，with history of hypertension and antiplatelet agents should be monitored regularly about number and position of CMBs，which could guide secondary prevention and treatment programs.