Objective To explore the changes and clinical signification of von Willebrand Fator Antigen（vWF：Ag），D-dimer（DD）and Fibrinogen Degradation Products （FDP）in acute cerebral infarction patients. Methods Levels of vWF：Ag， DD and FDP were measured by immune nephelometry. The differences of vWF：Ag， DD and FDP were analyzed between two groups. And the levels of vWF：Ag， DD and FDP were fol-lowed up for one year after the event. Results Totals of 94 patients with acute cerebral infarction were included［56（59.6%）males and 38（40.4%）females］. 120 healthy controls were included in the control group［68（56.7%） males and 52（43.3%）females］. Levels of vWF：Ag and DD in patients group were higher than that in control group（P＜ 0.01）. The logistic regression analysis showed that increasing of vWF：Ag and DD were risk factors of acute cerebral infarction. Levels of vWF：Ag and DD were positive correlated with score of NIHSS（r=0.625，0.510； P＜ 0.01）. Level of vWF：Ag was positive correlated with DD（r=0.688，P＜ 0.01）. Levels of vWF：Ag，DD and FDP in patients with poor prognosis were higher than that in patients with good prognosis（P＜ 0.05）. Conclu-sions Levels of vWF：Ag and DD are signifiantly increased in acute cerebral infarction patients，and positive correlated with NIHSS score. Detection of vWF：Ag and DD in acute cerebral infarction patients is contributed to the judgment of severity and prognosis of the disease.