Objective To investigate the clinical characteristics and diagnosis and treatment situation of patients using amphetamine-type stimulants （ATS）in voluntary rehabilitation hospital. Methods The medical record of hospitalized ATS users in voluntary rehabilitation hospital in Shanghai was retrospectively investigated，in-cluding their drug use history，clinical characteristic，diagnosis，treatment and prognosis. Results Two hundred and sixty six hospitalized ATS users were recruited. Male patients had significantly higher proportion of marriage and lowerproportion of previously using other substance than female patients （P＜0.05）. 50% of ATS subjects experienced the symptoms of hallucination，delusion，agitation，irritability，sleeping disorders and so on. 81.2% of subjects were diagnosed by ATS induced psychotic disorder. After about 10 d of hospitalization，the symptoms of 95.8% sub-jects could get obviously improved and were discharged from hospital. Conclusions The hospitalized ATS users showed high proportion of psychiatric symptoms，and there is gender difference in clinical characteristic features and substance use. Using the tailored intervention and increasing the attendance rate could improve the long-term rehabilitation for ATS patients.