Objective To investigate the effect of exposure in fetus and infancy on serum uric acid levels and the prevalence of hyperuricemia in adults. Methods Totals of 996 workers from Kailuan Group and Shijiazhuang steelworks were included. All subjects were divided into 3 groups：fetal exposure group （n=326），infancyexposure group （n=307）and control group （n=333）according to their earthquake exposure. Subjects in fetal exposure group were further divided into 3 subgroups：1-3 months fetal exposure group，4-6 months fetal exposure group and 7-9 months fetal exposure group. The levels of uric acid and incidence of hyperuricemia were compared among three groups. General baseline data were compared between hyperuricemia group and non-hyperuricemia group. While hy-peruricemia was ependent variable，contemporary body mass index（BMI），smoking，drinking，hypertension，diabetes mellitus，education，marital status，high density lipoprotein cholesterol（HDL-C），low density lipoprotein cholesterol（ LDL-C），Triglyceride（TG），total cholesterol（TC）were independent variables，logistic regression analysis was ana-lyzed. Results Compared with the control group，fetal exposure group and infancy exposure group showed signifi-cantly elevated serum uric acid （F=15.810，P＜ 0.01）. Incidence of hyperuricemia was significantly different among three groups （χ2=20.628，P＜0.01）. Fetal exposure group and infancy exposure group had significantly higher inci-dence of hyperuricemia than control group. And fetal exposure group had higher incidence of hyperuricemia than in-fancy exposure group. No significant differences were found in levels of uric acid and incidence of hyperuricemia among three subgroups in fetal exposure group （P＞ 0.05）. Logistic regression analysis showed that fetal and infancy earth-quake exposure were risk factors of hyperuricemia （OR=2.895，95%CI=1.652-5.075；OR=1.882，95%CI=1.044-3.394）. Conclusions Early earthquake stress experience is an important risk factor of adulthood high uric acid levels and hyperuricemia，especially pregnancy earthquake stress experience.