Objective To make a comprehensive analysis of the association between tryptophan hydroxylase（ TPH） gene A218C polymorphism and the susceptibility to schizophrenia. Methods Retrieval of literature on the relevance of schizophrenia and A218C in the domestic and foreign databases was conducted. Case-control studies published before May 2017 were obtained by screening in accordance with the inclusion and exclusion criteria. After evaluating the quality of literature， Stata 14.0 software was used to do Meta analysis on A218C polymorphism. Results A total of 11 case-control studies were incorporated， including 3 419 cases of schizophrenia and 4 048 controls. Meta analysis showed that TPH 218A allele can increase the susceptibility to schizophrenia， but with racial differences. The white people carrying A allele had a higher risk of suffering from schizophrenia. Conclusions TPH A218C gene polymorphism is associated with schizophrenia， which may be a risk factor for schizophrenia.