Objective To compare the clinical features of patients with epileptic comorbid bipolar disorder and with other mental disorders， so as to provide evidence for early identification and standard treatment in clinical practice for epilepsy comorbid with bipolar disorder. Methods This study was a retrospective study. All patients who were diagnosed as epileptic comorbid bipolar disorder and epilepsy comorbid with other mental disorders in Beijing Anding Hospital were investigated for clinical from 2014 to 2017. The data of patients' medical records were collated and analyzed by self-compiled information questionnaire. Results The differences between patients with epileptic comorbid bipolar disorder and with other mental disorders in education background， age of first episode， whether with high fever， with or without other causes， first diagnosis age of epilepsy， type of seizure， frequency of seizures， whether with the surgical treatment， ideal epilepsy control and IQ scores were statistically significant（ χ2=8.495，4.455，5.343，53.828，6.313，53.828， 17.697，59.889，6.313，8.495；P ＜ 0.05）. Multivariate Logistic regression model analysis showed that age of first episode（ OR=1.537，P=0.011）， ideal epilepsy control（ OR=1.595，P=0.028） were associated with bipolar disorder. Conclusions Patients with epileptic comorbid bipolar disorder have an older age of onset. Ideal epilepsy treatment and early recognition of bipolar disorder are beneficial to the prognosis.