Objective To evaluate the effect of doll intervention on the effect of clinical nursing of psychiatric patients. Methods Between April and October of 2017， a total of 61 female patients hospitalized in the Mental Health Center of Renmin Hospital of Wuhan University were recruited， and randomly divided into intervention group（ n=30） and control group（ n=31）. The patients of the control group received routine nursing care， while the patients of the intervention group were given doll intervention on the basis of routine nursing for 3 weeks. Patients were rated using Nurses' Observation Scale for Inpatient Evaluation（ NOSIE） and Kolcaba General Comfort Questionnaire（ GCQ） for the effect of intervention. Results The result of NOSIE indicated that after 3 weeks' intervention， the scores of social interest， delayed and depressive of the intervention group were（ 20.67±5.81），（ M=6） and（ M=4） respectively， which were all improved than those of the control group （15.16±7.17），（ M=2）， and（ M=2）（ P＜0.05）. The score of GCQ of the intervention group was（ 87.07±9.58）， which was significantly higher than that of the control group（ 79.81±7.94）， and the difference was statistically significant（ P=0.002）. Conclusions Doll intervention method is beneficial to the improvement of patient's comfort level and social interest， the reduction of the patient's delay and depression， and the effects of clinical nursing on the improvement of mental illness.