Objective To investigate the relationship among burden， coping style and social support in caregivers of Alzheimer disease patients. Methods A total of 84 patients with Alzheimer disease of the outpatients department of the Affiliated Brain Hospital of Guangzhou Medical University from May 2015 to September 2017 were selected. According to the situation of caregivers， all the subjects were divided into hospitalization group（ n=28）， family group（ n=35）， and institutional group（ n=21）. Zarit Caregiver Burden Interview（ ZBI）， Social Support Rating Scale（ SSRS） and Trait Coping Style Questionnaire（ TCSQ） were used to investigate and compare the burden， social support and coping style in caregivers. Results The total score of ZBI， scores of personal burden， responsibility burden， negative coping style and the total score of SSRS in the family group were significantly higher than those in the hospitalization group and the institutional group. The score of positive coping style in the institutional group was higher than that in the family group and hospitalization group， and the difference was statistically significant（ P＜0.05）. The ZBI total score， individual burden， responsibility burden were positively correlated with positive coping style（ r=0.85，0.86，0.82； P＜ 0.05）， and were negatively correlated with negative coping style（ r=-0.30，-0.29，-0.28；P＜ 0.05） and SSRS score（ r=-0.31，-0.27，-0.29；P＜0.05）. Multivariate stepwise regression analysis showed that negative coping， positive coping and total SSRS scores could explain 44.9% of the variation in total burden of caregivers.Conclusions The caregiver burden of Alzheimer disease patient is positively correlated with negative coping style， and positively correlated with positive coping style and social support.