Objective To investigate the comorbidity of Tourette syndrome（ TS）. Methods From June 2013 to May 2015， all TS patients of Beijing Anding Hospital were recruited. A cross-sectional study was carried out in the TS patients and their parents. The clinician surveyed the patient for general demographic information， TS prevalence and treatment status， and conducted a Mini International Neuropsychiatric Interview for children and adolescents（ MINI-Kid） for evaluation. Results A total of 414 patients were included in the analysis. After MINI-Kid re-diagnosis， the prevalence rate was 91.30%（378/414）， while the clinical diagnosis of comorbidity was only 10.39%（43/414）. After MINI re-diagnosis， it was found that TS had the largest number of patients with Attention Deficit Hyperactivity Disorder（ ADHD）， a total of 308 cases， accounting for 74.40% of the total number. Followed by major depressive disorder. The treatment rate of TS comorbidity was low in clinical practice. The highest treatment rate for TS comorbidity was obsessive-compulsive symptoms， which is only 22.20%（ 16/27）， following ADHD 10.06%（ 31/308）， manic episodes 9.76%（ 8/82）， and major depressive episodes 3.98%（ 8/201）. Conclusions The clinical recognition rate of TS comorbidity is low and the treatment rate is low.