Objective To explore the clinical efficacy of risperidone combined with lamotrigine in the treatment of the symptoms of auditory hallucination in patients with the abuse of amphetamine. Methods A total of 108 cases of amphetamine abuse patients with auditory hallucination as the main symptom were divided into study group（ 54 cases） and control group（ 54 cases） randomly. The study group was treated with risperidone combined with lamotrigine， while the control group was treated with risperidone only for 8 weeks. Efficacy and adverse reactions were assessed using the Positive Symptom Scale（ SAPS） hallucination subscale， the Brief Psychiatric Rating Scale（ BPRS， 18 items） and the Treatment Emergent Symptom Scale（ TESS）. The evaluation time was before treatment（ baseline） and the 4th or 8th week after treatment. Results The total score of SAPS hallucination in the study group at the 4th and 8th week after treatment were（ 9.35±2.16） and（ 1.80±1.02）， which were significantly lower than those in the control group（ 10.82±3.74） and（ 2.96±2.53）， and the group main effect was significant（ F=996.98，P ＜ 0.01）. There was no statistically significant difference in the incidence of akathisia， lactation or irregular menstruation between the two groups. Conclusions Risperidone combined with lamotrigine can significantly improve the auditory hallucinatory symptoms in patients with amphetamine abuse.