两种微创手术方法救治脑出血对早发性癫痫发生率的影响
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“ 复旦大学老年医学专项支持计划”资助课题(2016-39)


Effects of two minimally invasive surgical methods on the incidence of early onset epilepsy in the treatment of cerebral hemorrhage
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    摘要:

    目的 通过软通道定向钻孔引流和小骨窗开颅血肿清除两种手术方法治疗脑出血,探讨 术后早发性癫痫发作的发生率及其影响因素。方法 将83 例脑出血患者随机分为两组:定向软通道手 术组41 例和小骨窗手术组42 例,观察术后早发性癫痫发作的发生率,并分析两组患者早发性癫痫发作 与各影响因素的关系。结果 83 例患者中出现早发性癫痫发作者7 例(8.43%),其中定向软通道手术组 2 例(4.88%),小骨窗手术组5 例(11.90%)。两组发作类型以多种形式发生。单因素分析显示,累及皮质 的出血、再发脑出血、电解质紊乱及肺部感染者易发生早发性癫痫发作;Logistic 回归分析显示,出血部 位、出血次数、电解质紊乱及肺部感染者均与早发性癫痫发作的发生有关,其中皮质出血为独立的危险 因素。结论 软通道定向钻孔血肿引流手术治疗脑出血后早发性癫痫发作的发生率,比小骨窗开颅血 肿清除手术低。累及皮质的出血、再发脑出血、电解质紊乱以及肺部感染,是影响术后早发性癫痫发作 的重要因素,其中皮质出血为独立的危险因素。癫痫发作类型可以多种形式发生。

    Abstract:

    Objective Two surgical methods, soft channel surgery and small bone window, were used to treat cerebral hemorrhage, exploring the incidence of early onset epileptic seizure and its influencing factors. Methods A total of 83 cases of cerebral hemorrhage patients were randomly divided into two groups, with 41 cases in soft channel surgery group and 42 cases in small bone window surgery group. The incidence of early onset epileptic seizures was observed。 Statistical methods were used to analyze the relationship between early onset epileptic seizures and various influential factors in both groups. Results Among the 83 cases, 7 cases of early onset epileptics were reported, accounting for 8.43%, of which there were two cases of soft channel surgery( 4.88%), and 5 cases of small bone window surgery group( 11.90%). The types of attacks in the two groups were in various forms. Single factor analysis showed that the hemorrhage of the cortex, the recurrence of cerebral hemorrhage, electrolyte disturbance, and pulmonary infection were prone to premature epileptic seizures. Logistic regression analysis showed that bleeding site, bleeding times, electrolyte disturbance and pulmonary infection were all related to the occurrence of early epileptic seizures, in which cortical hemorrhage was an independent risk factor. Conclusions The incidence of early onset epileptic seizures after treatment of cerebral hemorrhage in the soft channel orienting borehole hematoma is lower than that in small bone windows. Hemorrhage of the cortex, reoccurrence of cerebral hemorrhage, electrolyte disorder, and pulmonary infection are important factors that affect early onset epileptic seizures. Cortical hemorrhage is an independent risk factor. Seizures can occur in many forms.

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迟风令 孙树杰 顾晔.两种微创手术方法救治脑出血对早发性癫痫发生率的影响[J].神经疾病与精神卫生,2018,18(2):
DOI :10.3969/j. issn.1009-6574.2018.02.009.

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  • 在线发布日期: 2018-05-16