Objective To systematically evaluate the efficacy of butylphthalide injection for post-stroke cognitive impairment. Methods The randomized controlled trials（ RCT） on butylphthalide injection therapy in cerebral infarction patients were collected by computer and manual retrieval. The data analysis was handled by the software Review Manager 5.0. Results Totally 13 studies involving 1 358 participants were contained in the Meta-analysis. The scores of National Institute of Health Stroke Scale（ NIHSS） were used to analyze the general efficacy of butylphthalide injection on stroke patients. The scores of Mini-mental State Examination（ MMSE）， Montreal Cognitive Assessment（ MoCA） scale and the level of superoxide dismutase（ SOD） were used to evaluate the improvement of cognition function after butylphthalide injection therapy. All the indicators mentioned above were compared at two time points， 14 days and 3 months after the beginning of the therapy， so as to evaluate the short-term and long-term effects of butylphtalide injection on cognition improvement. All the above results showed that the butylphthalide injection group was better than the control group. Conclusions The results of this systematic review showed that butylphthalide injection is more effective than conventional therapy in the treatment of cognitive dysfunction after cerebral infarction.