With the aging of the world population， the incidence of Alzheimer disease（ AD） increases gradually， which seriously affects human life. Therefore， effective treatment is urgently needed. In recent years， with the extensive application of genetic theory and gene knockout technology in the field of neurology， scientists have found that the neurogenesis of hippocampus and cortex is also affected by AD with genetic deletion. As neuron loss is a very important pathological feature of AD， neurons that induce nerve regeneration and replace death and functional degeneration in AD may be a cure for reversing AD. Adult neurogenesis not only opens up broad prospects for AD treatment， but also explores the etiology and pathogenesis of AD. Therefore， understanding the pathogenesis of adult neurogenesis may put forward a new strategy for the treatment of AD.