Objective To understand the anxiety and depression symptoms of outpatients in comprehensive medical institutions. Methods Non-probabilistic sampling method was used to investigate outpatients of 19 3A hospitals in 12 cities in China from March to August 2017. The survey was delivered to patient's cell phone through free WIFI in out-patient department. The internet panel survey was an anonymous and non-probability survey which contains PHQ-9 and GAD-7 scales. Results A total of 32 631 patients completed both PHQ-9 and GAD-7. 8 945 patients were screened as positive for depression， with a 27.41% positive rate. 70.30% of the patients were accompanied by moderate or above anxiety symptoms. Positive rate of anxiety was 38.29%， and 6 285（ 19.26%） patients were screened as positive for both depression and anxiety. The comorbidity was 19.26%. Positive rate was high in female than in male slightly. Conclusions The positive rate of depression or anxiety are quite high in patients of 3A general hospitals， and the comorbidity is also critical.