Objective To investigate the experience and efficacy of multi-lobe disconnection of cerebral hemisphere in refractory epilepsy. Methods A retrospective analysis was carried out in 22 patients with refractory epilepsy who underwent multi-lobe disconnection of cerebral hemisphere at Beijing Institute of Functional Neurosurgery from April 2013 to July 2017. The retrospective analysis included the introduction of operative method， the postoperative pathology and curative effect， and the complication records. Results During the follow up， 15 cases were in Engel Ⅰ（ 68%）， 6 in Engel Ⅱ（ 27%）， 1 in Engel Ⅲ（ 5%）. There were four patients of significant exacerbation of hemiplegia postoperatively， one patient of intracranial infection. There was no superficial cerebral hemosiderosis. Conclusions The multi-lobe disconnection of cerebral hemisphere can effectively treat the patients with refractory epilepsy caused by hemispheric lesions. This surgery is particularly indicated to the patients with hemispheric lesion， but without the deficit of the motor， sensory and language functions of the hemisphere.