Objective To explore the relationship between posttraumatic stress disorder（ PTSD） stress symptoms and blood homocysteine， folic acid， and vitamin B12 metabolism. Methods From November 2016 to November 2017， officers and soldiers stationed in Xinjiang were divided into PTSD group（ n=27） and non-PTSD group（ n=39） according to the positive result of PTSD Checklist- Civilian Version（ PCL-C） and Diagnostic and the diagnostic criteria of Statistical Manual of Mental Disorder（ DSM-5）. The fasting plasma homocysteine， folic acid， vitamin B12 and some other hematological indexes in the two groups were analyzed. Results The levels of serum homocysteine， folic acid， vitamin B12， T3 and T4 were significantly different between the two groups. However， there was no statistical difference in TSH， LDL， HDL-C. Conclusions The plasma homocysteine is higher in PTSD patients， folic acid and vitamin B12 are lower.