Objective To understand the relationship of the thromboelastogram（ TEG） parameters of patients with acute cerebral infarction（ ACI） and serum angiogenin-1（ Ang-1） and monocyte chemoattractant protein-1（ MCP-1） levels. Methods A total of 60 patients with ACI treated in Shandong Third Hospital from January 2016 to May 2018 were assigned as the observation group， and 60 healthy adults who Same to same hospital for physical examination at the same time were assigned as the control group. The levels of serum Ang-1 and MCP-1 and the TEG parameters were compared across the two groups. TEG parameters， serum Ang-1 and MCP-1 levels in patients with different severity of ACI in the observation group were compared and their correlations was examined. Results The α-angle， maximal amplitude（ MA）， coagulation index（ CI） and MCP-1 in the observation group were higher than the control group， and the R and K values， the Ang-1 in the observation group were lower（ P＜0.05）. There were significant differences in the TEG parameters， serum Ang-1 and MCP-1 in patients with different severity of ACI in the observation group（ P＜ 0.05）， such that the more severe the patient's ACI was， the lower the R and K values， Ang-1 were while the higher the α-angle， MA， CI and MCP-1 were（ P＜0.05）. Serum MCP-1 was positively correlated with α angle， MA and CI， and negatively correlated with R and K values（ P＜0.05）. Serum Ang-1 was negatively correlated with α angle， MA and CI， and positively correlated with R and K values（ P＜0.05）. Conclusions There is a good correlation between the parameters of thromboelastography and the level of vascular protection index Ang-1 and inflammatory response index MCP-1， which is not only helpful for the diagnosis of acute cerebral infarction， but also can be used to reflect the severity of illness and to guide the diagnosis and treatment.