Alzheimer disease（ AD） is a neurodegenerative disease characterized by abnormal deposition of amyloid β protein（ Aβ）， abnormal phosphorylation of tau， and degeneration and necrosis of neurons triggered by these. Studies have shown that hippocampal neurogenesis is closely related to AD. The treatment of hippocampal neurogenesis for AD has become a meaningful and promising study. This article discusses the research progress of the relationship between AD and hippocampal neurogenesis.