Acute ischemic stroke is the most common type of stroke. So far， alteplase is the only approved drug in the world to treat this disease. However， the clinical symptoms of some patients with thrombolysis have not improved， and even early neurological deterioration（ END） has occurred. END is not uncommon in clinical practice， but the definition of END does not have a unified concept. Its epidemiology， pathogenesis， and risk factors are still not fully understood. A large number of studies have shown that the occurrence of END is directly related to the poor prognosis of patients， so prevention and treatment of END is of great significance. In recent years， the problems mentioned above have been the hotspots discussed by many scholars in China and abroad. The above contents are reviewed in this paper.