Objectives To evaluate the efficacy of Danggui-Chengqi Decoction combined with lithium carbonate in the treatment of cognitive dysfunction in patients with manic episodes. Methods A total of 123 patients were randomly divided into 41 cases of Danggui-Chengqi Decoction group， 42 cases of -4.009，P=0.028）； the delayed recall score was higher in the combined group than that in the Danggui-Chengqi Decoction group（ t=-9.130，P=0.001） and the lithium carbonate group（ t=-6.447，P=0.015）.（ 3） The visualspatial difference and the difference in YMRS score were slightly positively correlated in the combined group （r=0.326，P=0.046）. In the Danggui-Chengqi Decoction group， there was a slight positive correlation between the visual-spatial difference and the difference in the YMRS score（ r=0.310，P=0.045）， and between the delayed recall difference and the difference in the YMRS score（ r=0.370，P=0.017）. Conclusions Danggui-Chengqi Decoction combined with lithium carbonate treatment can improve the cognitive function of patients with manic episodes， and the correlation with the improvement of mental symptoms is not strong. lithium carbonate group and 40 cases of Danggui-Chengqi Decoction combined with lithium carbonate group （combined group）. All patients were followed up for 8 weeks. Psychiatric symptoms and cognitive function were assessed before and after treatment using the Young Mania Rating Scale（ YMRS） and Repeatable Battery for the Assessment of Neuropsychological Status（ RBANS）. Results （1） The difference of YMRS between the three groups was statistically significant（ F=8.683，P＜0.001）. The difference of YMRS between the Danggui- Chengqi Decoction group and the lithium carbonate group was lower than that of the combined group（ t=-4.577， P＜0.001；t=-3.309，P=0.004）.（ 2） After treatment， the total scores of RBANS and its factor scores increased in all three groups（ P＜0.01）. In pairwise comparison， the total scores of RBANS and visual-spatial were lower in Dangui-Chengqi Decoction group than those in the combined group（ t=-24.500，P ＜ 0.001；t=-5.644， P=0.016）； the verbal ability score in the lithium carbonate group was lower than that in the combined group（ t=