Atherosclerosis is one of the most essential causes of ischemic vascular disease， while inflammation and cell death play an important role during its development. Pyroptosis is a programmed proinflammatory cell death proess. Recent studies have shown that the pyroptosis of endothelial cells， macrophages and smooth muscle cells accelerates the progress of atherosclerosis. Therefore，It may provide us a new method for the prevention and treatment of atherosclerosis-related diseasesa to have a better understanding of pyroptosis. This article aims at reviewing the relationship between pyroptosis and atherosclerosis.