早年应激对唐山矿业人群血脂影响的调查
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国家自然科学基金面上项目(81271489);河北省自然科学基金面上项目(H2014206280)


Study on the early stress effects on the blood lipid in Tangshan mining population
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    目的 调查胎儿及婴儿期经历应激的个体成年后血脂异常患病情况,并分析其影响因素。 方法 本研究为横断面研究,共收集1 260 例开滦矿业集团职工的人口学特征,根据出生日期分为婴儿 期地震暴露组372 例,胎儿期地震暴露组382 例,未暴露组506 例,评估空腹血糖(FBG)、甘油三酯(TG)、 总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)指标的差异。结果 婴儿期地震 暴露组高胆固醇血症、混合型高脂血症患病率高于胎儿期地震暴露组(18.8%比11.3%、13.4%比6.8%,P<0.05); 婴儿期地震暴露组血脂异常高于未暴露组(40.0%比27.7%,P< 0.05)。单因素分析显示饮酒、体质指数 (BMI)、地震应激分组是血脂异常的相关因素(χ2=4.432、6.612、7.690,P< 0.05)。非条件Logistic 回归分 析结果显示,饮酒的血脂异常患病风险是不饮酒者的1.590 倍(95%CI=1.102~2.294),婴儿期地震暴露组 血脂异常患病风险是未暴露组的1.723 倍(95%CI=1.147~2.589),BMI 消瘦型较超重/ 肥胖型对血脂是一 个保护性因素(OR=0.280,95%CI=0.080~0.972)。结论 婴儿期应激暴露组高胆固醇血症、混合型高脂 血症、血脂异常患病率较高,BMI 消瘦型是血脂的保护因素,饮酒、婴儿期应激暴露是血脂异常的危险 因素。

    Abstract:

    Objectives To investigate the prevalence of dyslipidemia in adults after stress in fetuses and infants, and to analyze the influencing factors. Methods This study is a cross-sectional study, recruited a total of 1 260 cases of the demographic characteristics from Kailuan Mining Group. According to the date of birth, there were 372 cases of infancy exposure group, 382 cases of fetal exposure group and 506 cases of unexposed group. The biochemical indexes of blood( FBG), triglyceride( TG), cholesterol( TC), high density lipoprotein cholesterol( HDL-C) and low density lipoprotein cholesterol( LDL-C) were evaluated. Results The rate of the prevalence of high TC hyperlipidemia and mixed hyperlipidemia in infant exposure group was higher than that of fetal exposure group( 18.8% vs 11.3%,13.4% vs 6.8%,P<0.05); the prevalence of dyslipidemia in infants exposure group was higher than that of unexposed group( 40.0% vs 27.7%,P<0.05). Single factor analysis of drinking, body mass index, and earthquake stress group were related factors of dyslipidemia (χ2=4.432,6.612,7.690;P < 0.05). The unconditional Logistic regression analysis showed that the risk of dyslipidemia was 1.590 times as high as that of non drinkers( OR=1.590, 95%CI=1.102-2.294). The risk of dyslipidemia in infant exposure group was 1.723 times higher than that in the unexposed group( OR=1.723, 95%CI=1.147-2.589). The BMI wasting type was more protective than the overweight / obese type( OR=0.280, 95%CI=0.080-0.972). Conclusions The prevalence of high TC, mixed hyperlipidemia and dyslipidemia is higher in infants exposure group. Low body weight is a protective factor for dyslipidemia. Alcohol consumption and infant exposure are risk factors of dyslipidemia.

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高媛媛 赵晓川 王育梅 李娜 李宁 王岚 宋美 于鲁璐 王学义.早年应激对唐山矿业人群血脂影响的调查[J].神经疾病与精神卫生,2019,19(5):
DOI :10.3969/j. issn.1009-6574.2019.05.002.

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  • 在线发布日期: 2019-08-22