Autism spectrum disorder（ ASD） is a serious neurodevelopmental disorder， which is the result of both genetic and environmental factors. In recent years， more and more findings have supported that intestinal microorganisms affect brain development through the gut-brain axis and produce corresponding behavioral phenotypes. The relationship between intestinal microbial disorders and ASD has been increasingly valued and it is more likely to be involved in the occurrence and development of ASD. The relationship between microbial-gut-brain axis and ASD is reviewed.