Objective To explore the application of intraoperative neurophysiological monitoring （IONM） in dorsal root entry zone（ DREZ） lesioning for chronic neuropathic pain. Methods A total of 10 patients with chronic neuropathic pain were treated with DREZ lesioning with IONM were analyzed retrospectively. Motor evoked potential（ MEP）， somatosensory evoked potential（ SEP） and electromyography（ EMG） were used for intraoperative neuroelectrophysiological monitoring. Clinical data were collected. Results Among the ten patients， six of them had pain after spinal cord injury. SEP， MEP and EMG of both lower limbs were monitored，and nerve roots or cauda equina were confirmed by nerve root traction stimulation. SEP was unrecordable in two patients and MEP was unrecordable in two patients. Four patients suffered from pain after brachial plexus avulsion. Two of them had upper limb amputated， and SEP and MEP of both lower limbs were monitored. SEP and MEP of all the limbs were monitored in unamputated patients， and SEP of the affected limb was unrecordable in one case. Among the ten patients， three patients had transient and more than 50% reduction in MEP， and 2 patients had transient and more than 50% reduction in SEP. Postoperative pain was significantly alleviated in all the ten patients， and the pain relief was greater than 70%. After the operation， four patients had mild hypoesthesia and decreased limb muscle strength. Two patients had mild dysuria. All the postoperative symptoms were transient changes， and no obvious postoperative complications were found. Conclusions The condition of patients undergoing DREZ lesioning is complex， and it is difficult to monitor neuroelectrophysiology during operation. However， the combination of MEP， SEP and EMG can effectively improve the success rate of operation and reduce the complications.