Alzheimer disease（ AD） is a progressive neurodegenerative disease， 70%-90% of AD patients have behavioral and psychological symptoms of dementia（ BPSD） at some point in the disease. Studies have shown that mood stabilizers can slow the loss of neurons and neurodegenerative processes and relieve BPSD. Mood stabilizers are often used in the treatment of BPSD and received good clinical effects. However， so far， the research outcomes on mood stabilizer in the treatment of BPSD are inconsistent. Using mood stabilizers to treat BPSD in AD is still off-label drug use. Therefore， the efficacy and safety of mood stabilizers in the treatment of BPSD of AD need to be determined by further scientific research， and the drug use instructions need to be updated as well， to make the treatment of BPSD with mood stabilizer well documented.