Ischemic stroke is one of the major diseases affecting human health and threatening human life. At present， the disease has been attracting more and more attention. As a regulatory gene in genome， long non-coding RNA （LncRNA） has very complex biological functions and plays important roles in many stages of cell biological activity， including mediating chromatin remodeling， mRNA alternative splicing， mRNA degradation and protein translation. Up to now， a variety of lncRNAs have been found to play an important role in the occurrence and development of cancers， cardiovascular diseases and neurodegenerative diseases. However，the researches on lncRNAs and ischemic cerebrovascular diseases are still limited. Therefore， this review mainly outlines research progresses between lncRNA and ischemic stroke.