Autism spectrum disorder （ASD） is a neurodevelopment disorder. The disease originated in infancy and manifested in three groups of symptoms， including different degrees of social communication disorder， language development disorder， narrow interest and rigid behavior. So far， there is no specific drug for the disease， but some studies show that oxytocin deficiency or underutilization is one of the causes of social interaction disorder in ASD patients. Therefore， studies on the effects of oxytocin on ASD have attracted attention from many scholar. This paper summarizes the symptom improvement， adverse reactions and application prospect of oxytocin in ASD patients， so as to explore new ideals for future research， and provide help for using OT to treat ASD clinically.