The incidence of mental disorders is increasing year by year， and the burden of disease is heavy， causing serious harm to the physical and mental health of patients and family social life. However， the medicine of mental disorders often reflects adverse reactions， and are difficult to tolerate， which leads to poor treatment compliance. In addition， the treatment of special groups， such as patients with severe physical diseases， adolescents and elderly patients， is limited by the safety of medication， which often makes it difficult for clinicians to make decisions. Wuling capsule is a species obtained from the rare medicinal fungus Wuling ginseng in China. It has a single component and is commonly used clinically for the treatment of mild and moderate depression， anxiety， and insomnia， as well as auxiliary treatment for severe depressive disorder. It is especially safe for patients with physical diseases. This paper mainly reviews the safety and effectiveness of Wuling capsule in various mental disorders.