Antipsychotic medications （APs） are the most important way to treat schizophrenia and other psychiatric disorders， especially the second-generation-antipsychotics（SGAs）， which are significantly related with weight gain in schizophrenia. APs with a high tendency of weight gain， such as clozapine and olanzapine， will affect the expression of immune genes and cause changes in serum cytokine levels， thus eventually downregulate neuroinflammation. Recently increasing evidence suggests that the APs changes the levels of cytokines to prevent the hypothalamus loop back by anorexia reaction energy balance， eventually lead to weight gain. This article reviews the relationship between serum cytokines and weight gain in schizophrenia. On this basis， it can provide references for clinicians to screen potential biomarkers of antipsychotic-induced weight gain.