Magnetoencephalography （MEG） and Electroencephalogram （EEG） （MEG/EEG） are both non-invasive neuroelectrophysiological technologies， which can detect synaptic dysfunction in the early stage of disease and track the disease progression. Although they imply special neurophysiological significance， they have not yet listed as biomarks for diagnosis of Alzheimer disease （AD） continuum so far. This paper discussed the role of MEG/EEG in the pathophysiological mechanism of the AD-continuum. This paper also reviewed the diagnostic value of MEG/EEG in pre-clinical and pre-dementia stage of AD and their effects in predicting disease progression of early AD patients.