Objective To study the significance of neuroendoscope-assisted microsurgery in the treatment of epidermoid cyst of cerebellopontine angle. Methods A total of 23 patients with epidermoid cyst of cerebellopontine angle were treated by neuroendoscope-assisted microsurgery. Tumor was gross-total resected under the microscope， and the residual tumor was removed by neuroendoscopy. Results After microscopic resection of the tumor， 18 cases were still found to have residual tumor through neuroendoscopy， and the tumor was further completely removed under endoscopy. Within a month after the operation， 18 cases of original symptoms disappeared， two cases of facial paralysis and one case of diplopia were relieved. One patient presented with delayed facial paralysis in one week after operation， and the patient recovered after a month of follow-up. Conclusions Endoscopic microsurgical resection of epidermoid cyst of cerebellopontine angle can prevent tumor residue， reduce complications and protect nerve function.