Schizophrenia is a serious mental illness， most of them are accompanied by cognitive impairment， which places a great burden on patients， families and society. Schizophrenia has a high heritable rate. In the past decade， many genetic variants associated with schizophrenia have been discovered， leading to a better understanding of the complexity of its genetic structure. Recent studies have also shown that genetic variants associated with schizophrenia affect cognitive ability. Further study on the effect of these genes on cognitive function will help us to understand the effect of genetic factors on cognitive dysfunction in schizophrenia. The purpose of this study was to investigate the relationship between CUB and SUSHI multiple domains-1 （CSMD1） gene polymorphism and schizophrenia and its cognitive impairment.