Disturbed Social and biological rhythm are widely observable in patients with bipolar disorder or depressive disorder. Clinical practice evidence suggests that interpersonal and social rhythm therapy （IPSRT） has a proven effect in stabilizing patients' social rhythm and improving their biological rhythm. This article reviews the biological rhythm in bipolar disorder or depressive disorder， theoretical basis， intervention methods and research progress of IPSRT. It also hopes to provide an effective treatment for patients with bipolar disorder or depressive disorder.