Amyotrophic lateral sclerosis （ALS） is a fatal neurodegenerative disease characterized by progressive degradation of motor neurons in the spinal cord， cortex and brainstem， leading to muscle weakness， myophagism， and spasticity. At present， the specific mechanism of ALS is unknown， and the mechanism of oxidative stress is a hot topic in recent years. This article reviews the relationship between oxidative stress and ALS.