Objective To explore the effect of semi-closed management on negative symptoms and social function in chronic schizophrenic patients with long-term hospitalization. Methods A total of 80 patients with chronic schizophrenia hospitalized in Shanghai Fengxian District Mental Health Center from September 2017 to September 2018 were enrolled prospectively. All the subjects were divided into the intervention group （n=40） and the control group （n=40）. The intervention group was given antipsychotics combined with semi closed intervention and farm labor management， while the control group was given antipsychotics combined with closed management for 12 months. All subjects were assessed by the Positive and Negative Symptom Scale （PANSS）， Scale of Social Function of Psychosis Inpatients （SSFPI）， and Insight and Treatment Attitude Questionnaire （ITAQ） before and after the intervention. Results The results of repeated measurement analysis of variance showed that the positive symptom factors indicating statistical significance in group main effect （F=4.887， P=0.030）， while the negative symptom factors indication statistical significance in both time and group interaction effect （F=6.249， P=0.015）. The score of negative symptoms of the intervention group decreased at the end of the 12th month. There was no significant difference in time main effect， group main effect， time and group interaction between the two groups （P＞ 0.05）. The social activity skills of SSFPI showed that there was significant difference in the main effect of time （F=9.648， P=0.003）， however there was no significant difference in the main effect of group and the interaction effect between group and time （P＞0.05）. There was no significant difference in the main effect of time， group main effect， time and group interaction between the two groups （P＞0.05）. The total score of ITAQ showed significant difference in time and group interaction effect （F=36.865， P＜0.001）. Conclusions Semi-closed management and farm labor can effectively improve the negative symptoms， selfknowledge and treatment attitude of long-term inpatients with chronic schizophrenia， but have no significant impact on social function.