Abstract:Alzheimer disease (AD), a chronic neurodegenerative disorder, is the main cause of dementia. Various factors contribute to AD with poor clinical prognosis. LncRNAs, a kind of non-coding intergenic RNA, are involved in various pathophysiologic processes, such as cancer, neural system disease, cardiovascular disease and aging via transcriptional and post-transcriptional mechanisms. The relationship between lncRNAs and the development of AD was first raised in 1992, and the role of different lncRNAs in AD has received extensive attention. This paper summarizes the studies regarding lncRNAs and AD during last decades and hope to get novel insights into prevention and treatment of AD.