Objective To evaluate the effects of computerized-assisted cognitive remediation therapy on patients with schizophrenia. Methods Randomized controlled trials （RCT） on computerized-assisted cognitive remediation therapy in the rehabilitation of patients with schizophrenia were searched for from databases such as PubMed， Web of Science， Cochrane Library， China academic journal full text database， VIP China Science and technology journal database， Wanfang Data medical journal database and other resources， with a time limit from establishment of the database to September 2020. Data were analyzed with RevMan 5.3 software. Results A total of 18 RCTs were included. The results of meta-analysis showed that computerizedassisted cognitive remediation therapy significantly relieved the symptoms ［positive symptoms： 95%CI（-2.34- -0.03），P=0.04； negative symptoms： 95%CI（-2.98--1.97），P ＜ 0.01； general psychotic symptoms： 95%CI （-2.07--1.25），P＜ 0.01； overall symptoms： 95%CI（-6.59--0.86），P=0.01］， also improved quality of life and social function ［quality of life： 95%CI（0.15-1.35），P=0.01； social function： 95%CI（0.20-1.37），P=0.009］. However， the results of enhancing interpersonal relationship and working ability were not statistically significant ［interpersonal relationship： 95%CI（-0.25-0.81），P=0.30； working ability： 95%CI（-0.62-0.18）， P=0.28］. Conclusions Computerized-assisted cognitive remediation therapy has positive effects on relieving the psychiatric symptoms， improving the quality of life， and enhancing social functions on patients with schizophrenia， but the effects on interpersonal relationships and working ability still need further study.