Abstract:Circular RNA (circRNA), a new class of endogenous closed non-coding RNA, which has been discovered in recent years and can be used as microRNA adsorption sponge, RNA-binding protein, transcription regulators and other ways to regulate the expression of target genes. It plays an important role in cell proliferation, migration, apoptosis, aging and other biological processes. CircRNA is highly expressed in the nervous system and cardiovascular system, and is widely involved in the occurrence and development of agerelated diseases through various mechanisms. Recent studies have shown that circRNA plays a key role in agerelated diseases such as Alzheimer disease, Parkinson disease and atherosclerosis. This article reviews the role and mechanism of circRNA in neurodegenerative diseases and atherosclerosis.