Bipolar disorder （BD） is a group of highly heterogeneous diseases， mostly occurring in early adulthood， but the pathological mechanism is still unclear. In recent years， there is evidence to support the hypothesis that "neurodevelopmental abnormality" may be involved in the pathogenesis of some BD patients， especially those with early-onset psychotic symptoms， providing a new direction for the study of its pathological mechanism. This paper reviews the evidence from perinatal risk factors， early clinical features， neuropsychology， brain imaging and genome.