Objective To understand the status quo of non-suicide self-injury behavior（NSSI） of adolescent with depression， and the difference of alexithymia and parenting style in depressive adolescent with and without NSSI. Methods A total of 241 adolescent depressive patients admitted to the Mental Health Center of West China Hospital from January 2018 to February 2019 were recruited as the research subjects. The Toronto Alexithymia Scale，EgmaMinnenavBardndosnauppforstran （EMBU） and Patients' Health Questionnaire-9 were applied in the investigation to explore the difference between NSSI group and non-NSSI group. Results Among 241 patients， 44.8% （108/241） adolescent had NSSI. Compared with patients without NSSI （n=133）， patients with NSSI showed significantly higher factor scores in punishment， over intervention，rejection/denying， and over protection from their fathers ［（24.80±7.36） vs （21.41±6.89）， （23.56±5.02） vs （21.74±4.66）， （13.44±4.39） vs （11.35±3.81）， （12.56±3.28） vs （11.20±2.94）， P＜ 0.05］，and over intervention/protection， rejection/denying， punishment from their mothers［（42.23±8.06） vs （37.73±7.80）， （18.65±5.85） vs （15.70±5.72）， （19.13±6.52） vs （15.97±6.20）， P＜ 0.05］. In the Toronto Alexithymia Scale， the factor scores of difficult to identify and describe their emotions were significantly higher in patients with NSSI than those without［（25.19±6.23） vs （22.12±7.09）， （18.06±4.19） vs （15.90±4.52）， P ＜ 0.05］. Conclusions NSSI has a high incidence in adolescents with depression. The alexithymia and parenting style was different between patients with and without NSSI.