Objective To discuss the influencing factors of medication adherence in patients with depression. Methods Patients with mild to moderate depression （n=102） were selected from the clinical data of mental disorders and the biological samples bank in Beijing Anding Hospital. According to the drug compliance， they were divided into two groups： the group with good compliance （n=40） and the group with poor compliance （n=62）. The influencing factors of drug compliance were explored by analyzing and comparing the differences between the two groups in age， gender， years of education， place of residence， marital status， living situation， family relationship， family economic status， frequency of attack， certain doctors and disease severity. Results According to the single factor analysis， there were significant differences between the group with good compliance and the group with poor compliance in terms of education years， living conditions， family relations， family economic status， attack frequency and fixed doctors （test value=8.516， 6.030， 6.706， 5.192， 5.170， 4.809， P＜ 0.05）. Logistic regression analysis showed that the above items in both groups were related to the compliance of patients with medication （P＜ 0.05）. Conclusions The patients with disharmonious family relationship， living alone， poor family economic status， frequent attacks， unstable doctors and low education level have lower drug compliance