Objective To explore the efficacy and safety of transcranial direct current stimulation（ tDCS） on patients with alcohol use disorder（ AUD）. Methods A total of 34 inpatients with AUD in Wuhan Mental Health Center were selected and randomly divided into study group（ 24 cases） and control group（ 10 cases） at a ratio of 2∶1. The study group received 1.5 mA of tDCS over the right anode/left cathode dorsolateral prefrontal cortex for 20 minutes during ten consecutive days， while the control group received sham tDCS treatment. Visual analog scale for craving， Hamilton Depression Scale， Hamilton Anxiety Scale， Pittsburgh Sleep Quality Index， Identification task， 2-back task and Stop signal task were used to assess the efficacy of tDCS before and after the intervention. The adverse reaction of patients were recorded during invention. Results Repeated-measure ANOVA showed that there was significant group and time interaction in Hamilton Anxiety Scale scores（ F=7.172，P=0.012）. Further analysis found that compared to the baseline， cue-induced craving， anxiety， depression and working memory were significant improved in the study group［ 3.50（0.00，5.53） vs 5.80（3.35，10.00），1.00（0.00， 3.00） vs 5.50（1.00，9.00）， 0.00（0.00，1.00） vs 2.00（2.00，6.00），（ 1.02±0.18） vs（ 0.84±0.20）， respectively，all P＜ 0.05］ ， which was not observed in the control group. Moreover， only the Hamilton Depression Scale score in the study group was lower than that of control group［ 3.00（0.50，3.00）］ after 10 days of intervention， with a statistically significant difference（ Z=-2.465，P=0.020）.The adverse reactions were mild and the difference of rates of adverse reaction between two groups was no statistical significance. Conclusions This study preliminarily demonstrated that tDCS may play a certain role in reducing cue-induced craving， depression， and anxiety and improving working memory in patients with alcohol use disorders. Serious aduerse reactions wasn's found.