Schizophrenia is a complex and serious mental disease， and its true pathogenesis is not yet clear. The inflammation hypothesis indicates that the neuroinflammation caused by the immune disorder of the human body is related to the pathogenesis of schizophrenia. In recent years， macrophage migration inhibitory factor（ MIF） is a cytokine with a wide range of immunomodulatory properties. It has been widely studied in various diseases. There is evidence that MIF is associated with schizophrenia. However， its main mechanism is unknown. This paper mainly describes the research progress of MIF in schizophrenia.